Racial-ethnic differences in MS underscore the complex interaction between genetic, biological, and environmental factors in the etiology of this disease. Prevalence and incidence of MS consistently have been shown to be lower among Hispanics and Asians relative to Caucasians. 6.9 cases per 100,000 person-years, respectively), particularly among African American women (14.7 per 100,000 person-years). In a more recent study from Southern California, MS incidence was found to be higher among African Americans than non-Hispanic whites (NHWs) between 20 (10.2 vs. The burden of MS has been shown to differ by race and ethnicity, with persons of African descent generally having a lower risk of MS than Caucasians however, this evidence is mostly based on ecological studies.
For example, the prevalence of MS is reported to be twice as high in the northern US compared with the southern US, which is consistent with other studies showing higher MS prevalence at colder, more extreme, northerly latitudes. The utility of national estimates of MS, however, is limited, as such estimates appear to differ by geographic region. Multiple sclerosis (MS) has been estimated to affect > 400,000 adults in the United States (US), but more recently this number was estimated at approximately 730,000, nearly twice what was previously calculated. Non-Hispanic blacks, especially women, were disproportionately affected and had less common, earlier progressive MS phenotypes. In this Northern Californian Cohort, between 20 the direct-standardised MS prevalence was estimated at 288.0 per 100,000 population, and increased over time. Non-Hispanic blacks compared with other groups more often had primary-progressive (10.0% vs. Age-adjusted prevalence ranged from 677.0 per 100,000 among non-Hispanic black women to 49.7 per 100,000 among non-Hispanic Asian men. The overall direct-standardised prevalence was 288.0 cases per 100,000 population (95% confidence interval: 276.3–299.8). Resultsġ,058,102 patients were identified, of which 3286 had MS. We performed a chart review of a racial-ethnic stratified sample of patients to examine disease phenotypes. MS prevalence estimates were standardised to distributions of gender and race-ethnicity for the underlying geographic region and stratified by gender and race-ethnicity with age adjustment. We conducted a retrospective, observational cohort study of adults (2010–2016).
The goal of this study was to quantify MS prevalence in a health care system in Northern California and examine differences in prevalence and phenotype by race-ethnicity. Research is needed to examine differences in multiple sclerosis (MS) prevalence by race-ethnicity.
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